#1. Marvel Cinematic Universe

- Domestic box office (inflation-adjusted): $9,144,251,845

- Worldwide box office: $22,557,315,232

- Movies: 31

- Years: 2008–present

The Marvel Cinematic Universe franchise averages more than two films per year and reigns supreme as the highest-grossing movie franchise in the history of the U.S. box office. Two of Marvel’s highest-grossing films are “Avengers: End Game,” at more than $858 million, and “Black Panther,” with more than $700 million at the domestic box office.

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